Cutting Edge: Antibody-Dependent Memory-like NK Cells Distinguished by FcRγ Deficiency

Cutting edge: antibody-dependent memory-like NK cells distinguished by FcRγ deficiency.

Because NK cells lack gene-recombination machinery and are thought to be relatively short-lived, it is unclear whether NK cells can mount long-term effective recall responses to reinfections by diverse pathogens. In this article, we report that FcRγ-deficient NK cells, which we recently identified and termed g(-)NK cells, possess distinct memory features directed by FcR-mediated Ab-dependent ta...

Cutting Edge: Antibody-Dependent Memory-like NK Cells Distinguished by FcRg Deficiency

Memory-like NK Cells Distinguished by FcR Cutting Edge: Antibody-Dependent

Cutting Edge: Salivary Gland NK Cells

Cutting edge: Priming of NK cells by IL-18.

Recent evidence suggests that NK cells require priming to display full effector activity. In this study, we demonstrate that IL-18 contributed to this phenomenon. IL-18 signaling-deficient NK cells were found to be unable to secrete IFN-gamma in response to ex vivo stimulation with IL-12. This was not due to a costimulatory role of IL-18, because blocking IL-18 signaling during the ex vivo stim...